Voriconazole used for Treatment of Tracheobronchial Aspergillosis: A Report of Two Cases
نویسندگان
چکیده
Tracheobronchial aspergillosis mainly involves the trachea, primary bronchus and segmental bronchus. the main symptoms including dyspnea, asthma and cough [1]. Based on clinical, bronchoscopic, and pathological presentations, Kramer and coworkers proposed a classification of tracheobronchial aspergillosis, they distinguished saprophytic, allergic, and invasive tracheobronchial aspergillosis (ITBA) [2]. Alternative treatments include liposomal or lipid complex form of amphotericin B, caspofungin, micafungin, posaconazole, and itraconazole [3]. The latest Infectious Diseases Society of America guidelines which recommend voriconazole for primary treatment of invasive Aspergillus tracheobronchitis [4], but only few reports on voriconazole for primary treatment of tracheobronchial aspergillosis [5-8], and evidence is limited. In this study, two cases on the adoption of voriconazole for the treatment of tracheobronchial aspergillosis were observed and reported as follows:
منابع مشابه
Successful treatment of larynx-tracheobronchial-pulmonary aspergillosis in an immunocompetent host.
Immunocompromised individuals are susceptible to pulmonary Aspergillus infections, whereas invasive Aspergillus infection is extremely rare in the presence of normal immunity. A case of larynx-tracheobronchial-pulmonary aspergillosis in an immunocompetent 57-year-old female host who was successfully treated with amphotericin-B and voriconazole is reported here.
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